It found that Budaprion XL mg. See FDA Review. That finding was accompanied by an admission: The original approval did not involve testing of the mg. Rather, only the mg. That methodology was chosen because it was viewed as unethical to expose volunteers to the higher dose — and the possibility of seizure — when dose proportional testing had always been deemed valid. See FDA Update.
In this instance, however, it was not scientifically appropriate to extrapolate the results. Why isn't bupropion the most frequently prescribed antidepressant? J Clin Psychiatry ;66 5 Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of anxiety symptoms in major depressive disorder: a meta-analysis of individual patient data from 10 double-blind, randomized clinical trials.
J Psychiatr Res, ;42 2 Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety anxious depression : a pooled analysis of 10 studies. J Clin Psychiatry, ;69 8 A pilot controlled trial of bupropion XL versus escitalopram in generalized anxiety disorder. Psychopharmacol Bull, ; Effect of treatment with bupropion on EEG sleep: relationship to antidepressant response.
Int J Neuropsychopharmacol. Antidepressants and their effect on sleep. Hum Psychopharmacol. Restless legs syndrome as side effect of second generation antidepressants. As well as being an antidepressant, bupropion is an antagonist at nicotinic receptors. This means that it blocks receptors where nicotine normally binds, making it useful in smoking cessation. Wellbutrin is taken by mouth as a milligram mg tablet, a mg tablet, or a mg extended release XR tablet.
The mg XR tablet is more popular. A person who is using the mg SR tablet will take one tablet twice a day. No single dose should exceed mg, and the daily dose should not exceed mg. The tablet should be taken in the morning and, in the case of the XR tablet, swallowed whole. Breaking or chewing an XR tablet increases the risk of an overdose, and possibly seizures. Wellbutrin has been trialed for use in ADHD , weight loss, and bipolar depression, but, so far, significant evidence only supports depression and smoking cessation.
Wellbutrin has been found to be at least as effective as other popularly prescribed antidepressant medication. There is also less chance of weight gain, sleepiness, and sexual dysfunction than with other forms of treatment. It may even work actively against sexual dysfunction resulting from previous antidepressant use.
It can take weeks or months for Wellbutrin to relieve the symptoms of depression. There is no fixed length of time for using it, but the patient may be advised to continue taking it, even when they feel better, to prevent the symptoms from recurring.
Patients with major depressive disorder who do not respond fully to SSRIs are sometimes prescribed Wellbutrin as an additional medication. Bupropion has been found to significantly reduce nicotine cravings. A course of treatment normally takes 7 to 12 weeks, but by day 10, the individual has often stopped smoking.
A person who wants to stop smoking may be prescribed a mg tablet of Zyban, or possibly Chantix, twice a day. It is best to use it without nicotine replacement therapy NRT. In the first days after starting treatment, the person may experience agitation, restlessness, and insomnia. Updated July College of Psychiatric and Neurologic Pharmacists.
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Side Effects. The 5 Major Classes of Antidepressants. Was this page helpful? Thanks for your feedback! Sign Up. What are your concerns? Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Related Articles. Cipralex for Depression. The 5 Most Used Antidepressants.
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